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REFLECTIONS
Hypertension
Hypertension Global Newsletter #9 2025

CONFERENCE CORNER Hypertension

The ESC Congress, hosted in Madrid, Spain on Aug 29 – Sept 1 , 2025, is the annual meeting of the
st
th
European Society of Cardiology. We present below some abstracts of interest that may have an impact
on clinical practice. Please click on the links to explore the abstracts in more detail.

ANTIHYPERTENSIVE DRUG STRATEGIES

1. Efficacy and safety of single-pill combination perindopril/amlodipine switched from combinations of other
reninangiotensin system inhibitors and calcium channel blockers: Results from ESPRIT trial. Presenter: Qiran Liang
(Fuwai Hospital, Beijing, China). ESC Congress 2025.

2. Efficacy and safety of low-dose antihypertensive combination drugs including amlodipine, telmisartan, and
chlorthalidone: A multicenter, randomized, double-blinded, parallel, phase III clinical trial. Presenter: Changgyu Park
(Korea University, Seoul, Korea). ESC Congress 2025.

3. Single-pill low-dose triple combination therapy versus standard-dose monotherapy in patients with mild to
moderate hypertension: Results from two randomized clinical trials. Presenter: Moo Yong Rhee (Dongguk University
Ilsan Hospital, Korea). ESC Congress 2025.

HYPERTENSION, DIABETES, AND MORTALITY

4. Rising mortality related to diabetes mellitus and hypertension: Trends and disparities in the United States (1999–
2023). Presenter: Chavin Akalanka Ranasinghe (Queen Elizabeth Hospital Birmingham, UK). ESC Congress 2025.

5. Hypertension-related vs diabetes-related cardiovascular deaths – Which is the bigger killer? A USA mortality trend
analysis using CDC WONDER. Presenter: Muhammad Farooq Khan (South Tyneside and Sunderland NHS Foundation
Trust, UK). ESC Congress 2025.

RISK ASSESSMENT AND PROGNOSIS IN HYPERTENSION

6. Risk of cardiorenal and metabolic outcomes in inadequately controlled hypertension: Insights from the ENLIGHTN
study. Presenter: Terry McCormack (University of Hull, UK). ESC Congress 2025.

7. Unraveling three decades of chronic kidney disease attributable to hypertension: A global epidemiological
perspective. Presenter: Anusha Parisapogu (Hartford Hospital, USA). ESC Congress 2025.

8. Impact of ethnicity in outcomes of major cardiovascular events in adult patients with hypertension: A meta-
regression analysis of 24 randomized trials. Presenter: Marco Bernardi (Sapienza University of Rome, Italy). ESC
Congress 2025.

9. Long-term change of blood pressure and risk of major cardiovascular disease in middle-aged and older adults with
prehypertension who did not take BP-lowering drugs. Presenter: Shuting Wang (Chinese University of Hong Kong, Hong
Kong). ESC Congress 2025.

10. Blood pressure in young adults from the general population in Norway strongly predicts cardiovascular events
after 22 years of follow-up. Presenter: Eirik Aaseth (Oslo University Hospital Ulleval, Norway). ESC Congress 2025.
11. Dynamic interplay of body mass index and hypertension: A 10-year longitudinal study revealing cumulative risk.
Presenter: Masanari Kuwabara (Jichi Medical University, Japan). ESC Congress 2025.

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